Chemistry, asked by baqira384, 1 year ago

What is Hofmann rule and its examples?

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Answered by Anonymous
1
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$$$${{{{{{{{{{.Hofmann elimination. ... With asymmetrical amines, the major alkene product is the least substituted and generally the least stable, an observation known as the Hofmann rule. This is in direct contrast to normal elimination reactions wherethe more substituted, stable product is dominant (Zaitsev's rule). }}}}}}}$$$$$$$$
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baqira384: Please give the examples of Hofmann elimination.
Anonymous: Hofmann elimination, also known as exhaustive methylation, is a process where a quaternary ammonium reacts to create a Tertiary amine and an alkene by treatment with excess methyl iodide followed by treatment with silver oxide, water, and After the first step, a quaternary ammonium iodide salt is created. 
Answered by Anonymous
13
Hofmann elimination. ... With asymmetrical amines, the major alkene product is the least substituted and generally the least stable, an observation known as the Hofmann rule.

This is in direct contrast to normal elimination reactions wherethe more substituted, stable product is dominant.
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