What is Krebbs Cycle ?
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Kreb cycle also called as Citric acid cycle or TCA cycle. The cyclic process through which acetyl Co-A is completely oxidized and co2 is released in step wise manner, is called kreb cycle
it is the second phase in the mechanism of aerobic respiration. it occurs in the matrix of mitochondria, IN presence of several enzymes and Co-enzymes,.during this phase coenzymes NAD and FAD take up the 2H+ Removed during oxidation step and NADH2 and FADH2 r formed. it involves a series of reactions each catalyzed by a specific enzyme.
the first stable compound of kreb cycle is citric acid (6-c) 0r citrate. chemically it is a tricarboxylic acid. hence kreb cycle is also called as citric acid cycle or tri carboxylic acid or TCA cycle. Various reactions of TCA cycle were discovered by sir Hans kreb in 1937 therefore it is popularly known as kreb cycle. The discovery of this pathway opened a new era in cellular biochemistry. hence sir Hans kreb was awarded Nobel Prize in biochemistry in 1953.
Citrate, the first product of cyclic reactions undergoes many changes and two decarboxylation steps and finally the initial acceptor of Acetyl CO - A, oxalo-acetate is regenerated. Acetyl fraction (2-c) is completely oxidised.
#its not copied from net. # from my notes
it is the second phase in the mechanism of aerobic respiration. it occurs in the matrix of mitochondria, IN presence of several enzymes and Co-enzymes,.during this phase coenzymes NAD and FAD take up the 2H+ Removed during oxidation step and NADH2 and FADH2 r formed. it involves a series of reactions each catalyzed by a specific enzyme.
the first stable compound of kreb cycle is citric acid (6-c) 0r citrate. chemically it is a tricarboxylic acid. hence kreb cycle is also called as citric acid cycle or tri carboxylic acid or TCA cycle. Various reactions of TCA cycle were discovered by sir Hans kreb in 1937 therefore it is popularly known as kreb cycle. The discovery of this pathway opened a new era in cellular biochemistry. hence sir Hans kreb was awarded Nobel Prize in biochemistry in 1953.
Citrate, the first product of cyclic reactions undergoes many changes and two decarboxylation steps and finally the initial acceptor of Acetyl CO - A, oxalo-acetate is regenerated. Acetyl fraction (2-c) is completely oxidised.
#its not copied from net. # from my notes
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