What is local Anaesthetics,explain
mechanism of action of Local
anaesthetics with example and give
their applications
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Answer:Local anesthetics produce anesthesia by inhibiting excitation of nerve endings or by blocking conduction in peripheral nerves. This is achieved by anesthetics reversibly binding to and inactivating sodium channels.Mechanism of action of local anesthetics — LAs reversibly inhibit nerve transmission by binding voltage-gated sodium channels (Nav) in the nerve plasma membrane. Nav channels are integral membrane proteins, anchored in the plasma membrane.
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