WHAT IS Malignant Fibrous Histiocytoma of Bone and Osteosarcoma.
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Answer:
Malignant Fibrous Histiocytoma is a sarcoma (malignant tumor) that can start in the bone or the soft tissue. MFH is the most common type of soft tissue sarcoma of the extremity while MFH of bone is fairly rare. It occurs more frequently in someone who is in their 50s and is a bit more common in men than women1.
The origin of the tumor is not known, meaning that the type of cell that this tumor arises from hasn’t been determined. Until 2002 this type of extremity sarcoma was called Malignant Fibrous Histiosarcoma (MFH) but in 2002, the World Health Organization changed the description of this type of tumor, renaming it undifferentiated pleomorphic sarcoma because of the inability to identify a specific cell type2 It is still often referred to as MFH.
There have been a number of ‘sub-types’ of MFH described over the past 20 years based on the variety of cell types seen in the tumor tissue.