Question

What is meant by the First-Pass Effect of drugs?

Answer 1

The first pass effect it is also known as first-pass metabolism or presystemic metabolism is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation.

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Answer 2

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✔️✔️First pass effect of drug-

The first pass effect (also known as first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation.

✔️✔️Let us make it clear with an example-

The effect of the most commonly considered active ingredient in cannabis, THC, is enhanced by transformation of a significant portion into 11-hydroxy-THC that more readily crosses the blood brain barrier and thus achieves greater potency than the original THC. [

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