Question

What is pepsinogen. How is it activated

Answer 1

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Pepsinogen is a substance which is secreted by the stomach wall and converted into the enzyme pepsin by gastric acid.

In the stomach, chief cells release a zymogen called pepsinogen, which is activated by hydrochloric acid (HCl) that released by the parietal cells in the stomach lining. Gastrin triggers the release of both pepsinogen and HCl when food is ingested. HCl creates an acidic environment, which allows pepsinogen to unfold and cleave itself in an autocatalytic process becoming pepsin.

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Answer 2

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Medical Definition of pepsinogen

:- a granular zymogen of the gastric glands that is readily converted into pepsin in a slightly acid medium.

Biochemistry

A substance which is secreted by the stomach wall and converted into the enzyme pepsin by gastric acid.

‘serum pepsinogen’

Activation of pepsinogen in the stomach. The peptidase in the stomach is pepsin. Pepsin works optimally in the acidic environment of the stomach, being active at pH 2-3, but becoming inactivated when the pH is above 5. The chief cells at the base of the gastric glands secrete the zymogen, which is called pepsinogen.

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