Question

What is Purine metabolism in human excretion

Answer 1

Purine catabolism pathway is one of the Nucleic acid Metabolism. Because nucleic acids are ubiquitous in cellular material, significant amounts are ingested in the diet. Nucleic acids are degraded in the digestive tract to nucleotides by various nucleases and phosphodiesterases. Nucleotides are then converted to nucleosides by base-specific nucleotidases and nonspecific phosphatases.           

Nucleosides are hydrolyzed by Nucleosidases or Nucleoside phosphorylases to release the purine base.

NMP + H2O           →     Nucleoside + Pi