Question

what is saytzeff rule.????

Answer 1

Saytzeff's rule is an empirical rule for predicting the favored alkene product in elimination reactions. While at the University of Kazan, Russian chemist Alexander Zaitsev studied a variety of different elimination reactions and observed a general trend in the resulting alkenes.

Saytzeff's Rule


Saytzeff Rule implies that base-induced eliminations (E2) will lead predominantly to the olefin in which the double bond is more highly substituted, i.e. that the product distribution will be controlled by thermodynamics.



The use of sterically hindered bases raises the activation energy barrier for the pathway to the product predicted by Saytzeff's Rule. Thus, a sterically hindered base will preferentially react with the least hindered protons, and the product distribution will be controlled by kinetics.

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Answer 2

Saytzeff's rule:

During intramolecular dehydration, if there is a possibility to form a carbon - carbon double bond at different locations, the preferred location is the one that gives more (highly) substituted alkene i.e., the stable alkene.