Question

What is the Derivative Of Barbituric Acid

Answer 1

Answer:

In contrast to barbituric acid, which is five times more acidic (pKa 4.0) than acetic acid (pKa 4.75), the 5,5-disubstituted derivatives are only weak acids (pKa about 8). This is of importance for their biological effects and for their analytical behavior. Under physiological conditions, barbituric acid is deprotonated, while 5,5-disubstituted analogues are mainly unionized and can cross the blood-brain barrier. For extraction from aqueous matrices, similar reflections apply: strong acidic pH values are not necessary for sufficient isolation.

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Answer 2

Explanation:

⏩barbituric acid is deprotonated, while 5,5-disubstituted analogues are mainly unionized and can cross the blood-brain barrier. For extraction from aqueous matrices, similar reflections apply: strong acidic pH values are not necessary for sufficient isolation.

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