? What is the relationship between HCL acid production
in the stomach and HCO₃
production by the pancreas?
Answers
The stomach is a gastrointestinal organ that is responsible for preliminary digestion and destroying any potential pathogenic microorganisms that may have been ingested. It is an acidic environment with a pH that can vary between 1.5-3.5.
This article will outline the production of stomach acid, the regulation of this and some clinical conditions that result from this process going wrong.
Hydrochloric Acid Production
HCl is produced by the parietal cells of the stomach. To begin with, water (H2O) and carbon dioxide (CO2) combine within the parietal cell cytoplasm to produce carbonic acid (H2CO3), catalysed by carbonic anhydrase. Carbonic acid then spontaneously dissociates into a hydrogen ion (H+) and a bicarbonate ion (HCO3–).
The hydrogen ion that was formed is transported into the stomach lumen via the H+– K+ ATPase. This channel uses ATP energy to exchange potassium ions in the stomach with hydrogen ions in the parietal cell.
The bicarbonate ion is transported out of the cell into the blood via a transporter protein called anion exchanger which transports the bicarbonate ion out the cell in exchange for a chloride ion (Cl–). This chloride ion is then transported into the stomach lumen via a chloride channel.
This results in both hydrogen and chloride ions being present within the stomach lumen. Their opposing charges leads to them associating with each other to form hydrochloric acid (HCl).
By TeachMeSeries Ltd (2020)
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Answer:
- HCl is produced by parietal cell in stomach
- pancreas secretes alkaline pancreatic juice containing copious amounts of bicarbonate (HCO3-) (23, 74). HCO3- plays essential roles in the digestive system.
Both HCl and HCO3 help in digesting the food.