what is the role of prolactin thyroid stimulating hormone????
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Thyroid Stimulating Hormone (TSH) - Stimulates the functioning of the Thyroid gland.
The purpose of the present study was to assess thyroid-stimulating hormone (TSH), prolactin, and growth hormone responses to TRH stimulation in 12 congenitally hypothyroid children adequately treated with L-thyroxine from the first weeks of life. Although clinically euthyroid, six of these childrenwere found to have abnormally high basal serum TSH concentrations despite clinical euthyroidism. Serum triiodothyroxine and L-thyroxine concentrations were normal and did notdiffer whether the children had elevatedor normal basal serum TSH. All six of the children with high basal TSH had anexaggerated TSH response to TRH and 4 of them also had an augmented prolactin response to TRH. The childrenwith normal basal TSH concentrations had normal TSH and prolactin responses to TRH. An abnormal elevation of growth hormone concentration in response to TRH was found in four of seven children in a separate group of patients who had prolonged, untreated primary hypothyroidism, but such responses were not found in any of the adequately treated children.
The purpose of the present study was to assess thyroid-stimulating hormone (TSH), prolactin, and growth hormone responses to TRH stimulation in 12 congenitally hypothyroid children adequately treated with L-thyroxine from the first weeks of life. Although clinically euthyroid, six of these childrenwere found to have abnormally high basal serum TSH concentrations despite clinical euthyroidism. Serum triiodothyroxine and L-thyroxine concentrations were normal and did notdiffer whether the children had elevatedor normal basal serum TSH. All six of the children with high basal TSH had anexaggerated TSH response to TRH and 4 of them also had an augmented prolactin response to TRH. The childrenwith normal basal TSH concentrations had normal TSH and prolactin responses to TRH. An abnormal elevation of growth hormone concentration in response to TRH was found in four of seven children in a separate group of patients who had prolonged, untreated primary hypothyroidism, but such responses were not found in any of the adequately treated children.
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Prolactin secretion is controlled by prolactin inhibitor factor that is secreted from hypothalamus, other factors like vaso active inhibitory peptide (VIP) and Thyroid relising hormone (TRH) cause to increase prolactin secretion (1). In fact, TRH in addition to increasing TSH causes to rise prolactin level (2).
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