what is the significance of JGA function in kidney?
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These cells contain the enzyme renin that can sense blood pressure. When glomerular blood flow (or glomerular blood pressure or glomerular filtration rate) decreases, it activates juxtaglomerular cells to release renin. Renin converts the angiotensinogen in blood into angiotensin I and further into angiotensin II.
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Significance of JGA function ...
JGA or Juxtaglomerular apparatus consisrs of cells of glomerulus, distal tubule, afferent and efferent arterioles.
JG cells are activated by fall in blood pressure and in return release renin . It converts angiotensinogen to angiotensin I and further to angiotensin II.
This angiotensin ll is a peptide hormone which plays the role of vasoconstrictor and increases blood pressure.
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