What is the sliding filament model of movement of muscles? How does the sliding movement occur at molecular level?
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Molecular mechanisms of skeletal muscular contraction
The sliding filament theory explains the mechanism of muscle contraction based on muscle proteins that slide past each other to generate movement.[1] It was independently introduced in 1954 by two research teams, one consisting of Andrew F. Huxley and Rolf Niedergerke from the University of Cambridge, and the other consisting of Hugh Huxley and Jean Hanson from the Massachusetts Institute of Technology.[2][3] It was originally conceived by Hugh Huxley in 1953. Andrew Huxley and Niedergerke introduced it as a "very attractive" hypothesis.[4]
According to the sliding filament theory, the myosin (thick) filaments of muscle fibers slide past the actin (thin)filaments during muscle contraction, while the two groups of filaments remain at relatively constant length. Before the 1950s there were several competing theories on muscle contraction, including electrical attraction, protein folding, and protein modification.[5] The novel theory directly introduced a new concept called cross-bridge theory (classically swinging cross-bridge, now mostly referred to as cross-bridge cycle) which explains the molecular mechanism of sliding filament. Cross-bridge theory states that actin and myosin form a protein complex (classically called actomyosin) by attachment of myosin head on the actin filament, thereby forming a sort of cross-bridge between the two filaments. These two complementary hypotheses turned out to be the correct description, and became a universally accepted explanation of the mechanism of muscle mov
Molecular mechanisms of skeletal muscular contraction
The sliding filament theory explains the mechanism of muscle contraction based on muscle proteins that slide past each other to generate movement.[1] It was independently introduced in 1954 by two research teams, one consisting of Andrew F. Huxley and Rolf Niedergerke from the University of Cambridge, and the other consisting of Hugh Huxley and Jean Hanson from the Massachusetts Institute of Technology.[2][3] It was originally conceived by Hugh Huxley in 1953. Andrew Huxley and Niedergerke introduced it as a "very attractive" hypothesis.[4]
According to the sliding filament theory, the myosin (thick) filaments of muscle fibers slide past the actin (thin)filaments during muscle contraction, while the two groups of filaments remain at relatively constant length. Before the 1950s there were several competing theories on muscle contraction, including electrical attraction, protein folding, and protein modification.[5] The novel theory directly introduced a new concept called cross-bridge theory (classically swinging cross-bridge, now mostly referred to as cross-bridge cycle) which explains the molecular mechanism of sliding filament. Cross-bridge theory states that actin and myosin form a protein complex (classically called actomyosin) by attachment of myosin head on the actin filament, thereby forming a sort of cross-bridge between the two filaments. These two complementary hypotheses turned out to be the correct description, and became a universally accepted explanation of the mechanism of muscle mov
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Actually to the sliding filament is a concept about how muscle works.
According to this concept thick myosin filament of muscle, slice over the thin actin filament of muscle during the muscle contraction.
And the whole procedure is happening in molecular level, so there is no another specific reason for how does this procedure happens in molecular level.
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