what is the specific function of cardiac muscle...???
Answers
Their rhythmic contraction and relaxation helps in pumping action of heart.
Cardiac muscle has a low regenerative potential, in case of heart attack the injured area heals and the native tissue is replaced by a scar. This events lead to a loss of contractile myocardium, scar tissue being unable to contract.60 In this context, tissue engineering plays a crucial role in cardiac muscle repair aiming to the development of cardiac muscle tissue grafts characterized by adequate size, homogeneous cell distribution, responsiveness to electrical stimulation, evidence of cardiac markers, and mechanical integrity.61 Zimmermann and coworkers created a large tissue graft from neonatal rat cardiac cells using a specific device able to apply a unidirectional cyclic stretch to the construct. The engineered heart tissue once implanted in a preclinical model of myocardial infarct showed electrical coupling to the host tissue. This property was essential to enable the graft to effectively support the cardiac contractile function.62
Cardiac muscle has a low regenerative potential, in case of heart attack the injured area heals and the native tissue is replaced by a scar. This events lead to a loss of contractile myocardium, scar tissue being unable to contract.60 In this context, tissue engineering plays a crucial role in cardiac muscle repair aiming to the development of cardiac muscle tissue grafts characterized by adequate size, homogeneous cell distribution, responsiveness to electrical stimulation, evidence of cardiac markers, and mechanical integrity.61 Zimmermann and coworkers created a large tissue graft from neonatal rat cardiac cells using a specific device able to apply a unidirectional cyclic stretch to the construct. The engineered heart tissue once implanted in a preclinical model of myocardial infarct showed electrical coupling to the host tissue. This property was essential to enable the graft to effectively support the cardiac contractile function.62A different approach is the one shown by Vunjak-Novakovic and colleagues who firstly exploited electrical signals to encourage the development of a functional engineered cardiac tissue.63 Pulsatile electrical stimulation was applied to reproduce the physiological condition of the native tissue on neonatal rat cardiomyocytes seeded in collagen scaffolds. The study revealed the elongation of cardiac muscle fibers, the increase in cardiac cell markers expression, and the improvement in the tissue structure together with an adequate contractile activity.64