Question

what kind of disease is sickle cell Anemia?​

Answer 1

In all type of sickle cell disease, at least one of the two abnormal genes causes a person's body to make haemoglobin S.

When a person habit to hemoglobin S genes, the disease is called sickle cell Anemia

Answer 2

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Sickel cell anaemia ::

❇It is a medalian disorder.

❇ It is a autosomal linked recessive trait.

❇This disease is controlled by a single pair of allele.

❇ This disease is Transmitted from the parents to the offspring when both are carrier of a gene.

Causes of Sickle cell anaemia ::

❇ The disease is caused due to the substitution of glutamic acid by valine. at the 6 th position of the beta globin chain. of haemoglobin.

❇ The amino acid is changed from

" GAG --- GUG "

❇The mutant haemoglobin molecule undergoes polymerisation under low oxygen tension causing change in shape of RBC.

❇From biconcave to sickle shape.

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