What logic suggests that the chromosomal integration of tumor virus genomes is an
intrinsic, obligatory part of the replication cycle of RNA tumor viruses but an inadvertent
side product of DNA tumor virus replication?
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Oncogenesis can be induced by chronic and acute RNA tumor viruses through a promoter/enhancer insertion mechanism and through a transforming protein coded by a viral oncogene (v-onc), respectively. A hypothetical trans-activating mechanism is invoked by retroviruses with trans-activating regulatory proteins.
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