When cells are exposed to heat via various means there is release of protein called hsps. The hsps are up regulated intracellular proteins called molecular chaperones that prevent protein aggregations and help transport repair proteins while the extracellular hsps enhance the immune system
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Extracellular heat-shock proteins (HSPs) interact with the immune system in a very complex manner. Many such HSPs exert powerful effects on the immune response, playing both stimulatory and regulatory roles.
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