Question

when did the American settlers move into the Mississippi Valley
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Answer 1

Answer:

Between 1785 and 1800

Between 1785 and 1800, there were migrations south into the wilderness of western Georgia and the Mississippi Valley. People from Pennsylvania, Maryland, and Virginia went southward along the east side of the Appalachian Mountains over the Great Valley Road. Some turned west through the Holston and French Broad Valleys into Tennessee.