when the plague virus was held
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The Plague of Justinian arrived in Constantinople, the capital of the Byzantine Empire, in 541 CE.
The plague never really went away, and when it returned 800 years later, it killed with reckless abandon. The Black Death, which hit Europe in 1347, claimed an astonishing 200 million lives in just four years.
London never really caught a break after the Black Death. The plague resurfaced roughly every 20 years from 1348 to 1665—40 outbreaks in 300 years. And with each new plague epidemic, 20 percent of the men, women and children living in the British capital were killed.
By the early 1500s, England imposed the first laws to separate and isolate the sick.
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1720 is the correct answer.
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