where does the development of gametocytes take place?
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The malaria parasite life cycle also comprises a phase of sexual reproduction which takes place in the mosquito vector, but the actual switch to sexual development occurs in the vertebrate host, with the formation of male and female gamete precursors (gametocytes), and is a prerequisite for transmission of disease
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However, it is known that developing gametocytes also sequester in vivo. Only mature stage V gametocytes (and probably also sexually committed ring stage parasites) appear in the circulation. Early reports indicated that the spleen and bone marrow are the predominant sites occupied by developing gametocytes .
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