Question

Which drug may inhbit hepatic microsomal p450 enzyme and is responsible for warfain metabolism?

Answer 1

Answer:

Identification and characterization of metabolites is a critical step in the long and expensive process of bringing a new chemical entity to market. For drug candidates, every significant metabolite must be identified, and sufficient quantities synthesized to meet MIST requirements.

Until now, the synthesis and purification of several milligrams of some metabolites represented a slow and expensive step in the development process, often involving incubation with human or rat liver microsomes (or expensive recombinant systems) – typically yielding complex HPLC profiles and requiring multiple isolation and purification procedures.

Answer 2

Answer:

Drug metabolism may be perturbed by genetically deter- ... P450 enzymes. ... whether variant alleles were responsible for altering warfarin ... Major role of human liver microsomal.