which immune system cells is responsible for celiac disease ?
Answers
Answer:
By the 1980s and 1990s, researchers understood that T cells (adaptive immune cells) were involved in the immune response to gluten and the development of celiac disease. They also understood that B cells made antibodies that recognized a normal protein in the intestine called tissue transglutaminase or tTG.
Explanation:
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Answer:
researchers understood that T cells (adaptive immune cells) were involved in the immune response to gluten and the development of celiac disease. They also understood that B cells made antibodies that recognized a normal protein in the intestine called tissue transglutaminase or tTG.
T Cells
Like all immune cells, T cells have receptors (in this case called T cell receptors) that recognize antigens. Once the antigen is recognized, the T cell becomes activated. Activated T cells are responsible for destroying the pathogen, either directly by killing the infected cell, or indirectly by activating B cells or innate immune cells—this is often called the cell-mediated immune response.
the 3 types of T cells described above, the CD4+ T helper cells play a leading role in celiac disease. These are the cells that mistakenly recognize gluten as a pathogen and trigger an immune response . However, cytotoxic CD8+ T cells known as intraepithelial lymphocytes (IELs) are also important as they are drivers of tissue damage in the intestine.