Question

Which is the best leaving group in a substitution reaction of an alkyl halide?

Answer 1

Answer:

A leaving group is a nucleophile acting in reverse; it accepts a lone pair as the bond between it and its neighbor (usually carbon for our purposes) is broken.

Answer 2

Which is the best leaving group in a substitution reaction of an alkyl halide?

Explanation:

• Alkyl chlorides are indeed common reactants in laboratory nucleophilic substitution reactions, as are alkyl bromides and alkyl iodides.
• Good leaving groups are weak bases. They're happy and stable on their own.
• Some examples of weak bases: halide ions (I-, Br-, Cl-) water (OH2), and sulfonates such as p-toluenesulfonate (OTs) and methane sulfonate (OMs). The weaker the base, the better the leaving group.