Question

Which of the following statement relating to the protein binding of drug is not
true -
O Protein binding decreases the free drug concentration
O Protein binding to plasma albumin is a reversible process
O Prolongs the duration of action of a drug
O protein bound drug is pharmacologically active​

Answer 1

$O Prolongs \: the \: duration \: of \: action \: of \: a \: drug$

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Answer 2

The correct answer is (d) protein-bound drug is pharmacologically active​.

• Plasma and tissue protein restricting of medications is a central point that influences both pharmacokinetics and pharmacodynamics of the medication.
• It is typically the free (unbound) type of the medication that can apply pharmacological action, while the bound type of the medication is generally pharmacologically latent.
• Diminished plasma protein restricting prompts an increment in free plasma part causing an increment in volume of dissemination and a more limited end half-life.
• The increment in the clear volume of dissemination and the more limited end half-life cause an abatement in absolute plasma fixation.
• Protein-restricting may influence drug action in one of two ways: either by changing the powerful convergence of the medication at its site of activity or by changing the rate at which the medication is dispensed with, in this way influencing the period for which viable fixations are kept up with.