Question

Which of the following (to be
converted by functional group
interconversion, FGI) is not a good
alternative target for the synthesis
of a primary amine, RCH2NH2?
Options
ORCH2CI
ORCH2OH
ORCHO
O RCN​

Answer 1

Answer:

RCHO

As its a aldehyde compound

Answer 2

ORCHO (Aldehyde)

Explanation:

• Primary amines is also synthesized by alkylation of ammonia. If the primary amine is the desired product, a large excess of ammonia is used.
• Amides yield primary amines by reduction with lithium aluminum hydride, as N‐substituted and N, N‐disubstituted amides respectively produce secondary and tertiary amines due to amides are easily prepared, their reduction is a chose method for making all classes of amines.
• Primary amines were prepared selectively with no or minimum formation of the secondary and tertiary amine as product. The procedure was performed on a range of functionalized aldehyde substrate which include in situ results in aldehydes from a Vasella reaction.