Question

Which one of the following coordination compounds is used
to inhibit the growth of tumours?
(a) Trans-platin (b) EDTA complex of calcium
(c) [(Ph₃P)₃RhCl] (d) Cis-platin

Answer 1

i think the correct answer is (c)

Answer 2

Coordination compound which is used to inhibit the growth of tumors is :

• Cis platin

•The design of metal-based anticancer drugs was initiated by cisplatin (cis-Pt(NH3)2Cl2), one of the leading agents in clinical use with a high cytotoxic effect upon a variety of tumour types, in particular against testicular, ovarian, head and neck, and bladder carcinomas, as well as lymphoma.

•The therapeutic target of platinum complexes is DNA, via binding to the purine bases through 1,2-intrastrand cross-links, yielding one or more 1,2-d(GpG) and 1,2-d(ApG) bifunctional adducts in which the two chlorine atoms of the cisplatin molecules are replaced (upon hydrolysis) by N7 atoms of adjacent purines.