Question

Why aerobic respiration and glucose availability is less in ischaemia?

Answer 1

Ischaemia is the stoppage of blood supply to other vital organs and tissues becomes of which there is a shortage and deficit in oxygen which is very much needed to complete the cellular metabolism of the cells and generally to make the tissue in a working state or alive (restriction or stoppage causes permanent death of the tissue or muscle). It is resulting due to dysfunctional cases of the tissue and abnormalities in the blood vessels and can also be the case of a congestive failure in a part of body, such as, in legs if the supply of blood is stopped then it will or might lead to pulmonary thrombosis or vasoconstriction of blood vessels making a blood clot which can travel higher to vital organs causing stoppage in oxygen supply and a clot in that particular organ, leading to death or permanent haemorrhage. Due to low oxygen level the cells will need to perform aerobic respiration to obtain glucose in a higher level or state, the viability on a critical supply of glucose will depend upon the need of the tissue and metabolic ontervention by restriction in glucose and oxygen levels. In this case we cannot consider it as a highly aerobic tissue in need for some external supplicant provided to vital part. The heart and the brain are the main organs or tissues which are mostly responsible to keep a human alive and for this they require high amounts of oxygen and henceforth use that much as they are metabolically active to a really great level, for this they use a lot of resources and for this they require oxygen. This further leads to cutting down of the total oxygen and leads to lower production in glucose for cellular metabolism, but, there can be a exception, this will never or does not reflect the pathophysiology of the proper need of glucose as there are other alternatives for obtaining fuel or resource to keep the organ or tissue alive. It will not limit the glucose from the bloodstream by the decreased blood flow the cells, for cellular metabolism, can still use glycogen and other lymphatic fat stores for fuel consumption. So, in a nutshell, this makes tissues and organs starved out of oxygen making them to extract oxygen in higher and higher amounts, further more, leads to less likely performed aerobic respiration as it needs oxygen to perform the process too, affects, lastly, the final obtained product or glucose. Therefore, aerobic respiration and glucose availability is usually less in ischaemia, but, alternatives are always there to protect the body system too.