why can a single endocrine hormone produced a wide spread of response in a body than a single nerve cell
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Because only those target cells have receptors for that particular hormone. Some hormones bind to receptors on the surface of target cells. Others enter the cells and bind to receptors in the cytoplasm or nucleus.
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So why do hormones affect only their target cells in particular tissues? Because only those target cells have receptors for that particular hormone. Some hormones bind to receptors on the surface of target cells. Others enter the cells and bind to receptors in the cytoplasm or nucleus.
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