Why conversation of animal is necessary
Answers
Answer:
Understanding the concept of extrapolation of dose between species is important for pharmaceutical researchers, when initiating new animal or human experiments. Interspecies allometric scaling for dose conversion from animal to human studies is one of the most controversial areas in clinical pharmacology. Allometric approach considers the differences in body surface area, which is associate with animal weight, while extrapolating the doses of therapeutic agents among the species. This review provides basic information about translation of doses between species and estimation of starting dose for clinical trials using allometric scaling. The method of calculation of injection volume of parenteral formulation based on human equivalent dose is also briefed.