why do humans get old ?
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Over time, telomeres shorten, which is associated with disease and aging. Programmed senescence theory. Cellular senescence occurs when cells stop dividing and growing, but don't die. This theory suggests that this causes aging
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Methylation of DNA slows over time, which creates an aging biomarker, so if we measure how much DNA of an individual has been methylated, we can estimate their biological age. Some genes may also become hypermethylated with age causing them to loose function, such as the estrogen receptor.
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