Question

Why does a large increase in temperature slow down a reaction catalysed by an enzyme?

Answer 1

This is because catalysts are very specific .

They work only at a certain range of temperature.

That is the characteristics of the enzyme .

So at high temperatures the efficiency of enzyme reduces over 40 C because its optimum temperature is 35 C - 40 C.

Hence it slows the reaction instead of increasing it.

Answer 2

As the enzyme molecules become saturated with substrate, this increase in reaction rate levels off. ... At low temperatures, an increase in temperature increases the rate of an enzyme-catalyzed reaction. At higher temperatures, the protein is denatured, and the rate of the reaction dramatically decreases