Why does a woman’s age impact the risk of Down syndrome in her baby?
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Why does a woman’s age impact the risk of Down syndrome in her baby?
June 6, 2017
New Patient Appointment
or 214-645-8300
New Patient Appointment
or 214-645-8300
Robyn Horsager-Boehrer, M.D.
Robyn Horsager-Boehrer, M.D.
Obstetrics & Gynecology
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Women over age 35 are at higher risk for giving birth to a child with Down syndrome.
People have long recognized there is a connection between maternal age and Down syndrome.
In the early 1900s, researchers noticed children with the condition were frequently the last-born in large families and came shortly before a woman experienced menopause. At the time, they believed the condition was a sign that the mother had simply exhausted her reproductive potential.
Decades later, a French pediatrician made the association between the condition and an extra chromosome that was present in skin cells of some of his patients. We now understand even more about Down syndrome, including another cause that may run in families and is not associated with a woman’s age at the time she conceives.
But what’s really groundbreaking is we are starting to understand why maternal age matters for the development of Down syndrome.
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Answer:
A woman's risk of having a baby with chromosomal abnormalities increases with her age. Down syndrome is the most common chromosomal birth defect, and a woman's risk of having a baby with Down syndrome is: At age 20, 1 in 1,441.
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