Why does drugs always contain only weak acid and weak base
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Most drugs are salts of either weak acids or weak bases. They are absorbed in the undissociated, lipid soluble, form. The dissociation of weak acids is suppressed by low (acid) pH. Thus, theoretically, one would expect a weak acid to be absorbed, primarily in the stomach which has a low pH. However, the amount absorbed in the stomach, depends on how long the drug remains in the stomach. If it passes into the small intestine, even though the pH is higher, it will be absorbed there, particularly as the transit time is much longer, and there is a much greater absorbing area.
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