Question

Why doesn't gastric juice destroy the stomach cells that make it?

Answer 1

Answer:

Gastric juice does not destroy stomach cells that make it because all these ingredients remain inactive until they are released into the lumen. Pepsinogen and HCl are first secreted into the lumen of the stomach. Hydrochloric acid converts the pepsinogen (inactive form) into pepsin.

Explanation:

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Answer 2

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The stomach is protected from self-digestion by the mucosal barrier. This barrier has several components. First, the stomach wall is covered by a thick coating of bicarbonate-rich mucus. This mucus forms a physical barrier, and its bicarbonate ions neutralize acid.