Question

why heroin is more potent than morphine​

Answer 1

Explanation:

Studies investigating the reinforcing and analgesic activity of heroin and morphine have found that heroin is a more potent compound.

Answer 2

Answer:

Replacing the hydrogen-bonding -OH groups with -OCOCH3 makes heroin much less soluble in water than morphine, but more soluble in non-polar solvents, like oils and fats. Therefore heroin has to be injected directly into the bloodstream, but once there it can pass rapidly through the blood-brain barrier which normally prevents the passage of water-soluble and large molecules. As a result it is much more potent than morphine, but its effect does not last as long. Again, once the heroin molecule is absorbed into the body, the acetyl groups are removed, reforming morphine.

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Explanation: