Why is calcium needed for breaking vesicles instead nerve impulse can do the same?
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The transmission of a nerve impulse along a neuron from one end to the other occurs as a result of electrical changes across the membrane of the neuron. The membrane of an unstimulated neuron is polarized—that is, there is a difference in electrical charge between the outside and inside of the membrane.
Neurotransmitter release is triggered by the opening of 'voltage‐sensitive' calcium channels, the admission of a small pulse of Ca2+ ions and the binding of these ions to the neurotransmitter secretion apparatus culminating in the fusion and discharge of a transmitter‐filled secretory vesicle.
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