Why is haemophilia more common in males than in females?
Answers
Answer:
As the gene of hemophilia is linked to x chromosome.. And is resecive in nature
Men have only one x chromosome.. While women have 2 of them... So women wont get affected by one hemophilic chromosome .. While men will get affected... . So their chances are high
Answer:
The genes for blood clotting are located on the X chromosome. Males have one X and one Y chromosome (XY) and females have two X chromosomes (XX). Males inherit the X chromosome from their mothers and the Y chromosome from their fathers. Females inherit one X chromosome from each parent.
Since females have two X chromosomes, a mutation must be present in both copies of the gene to cause the hemophilia. Males are affected by X-linked recessive disorders much more frequently than females.
So, haemophilia is more common in males than in females
Explanation:
Hemophilia is a rare inherited bleeding disorder where the blood fails to clot normally due to a lack of blood clotting proteins (clotting factors). The condition leads to spontaneous bleeding and bleeding after surgery or injuries.
While small cuts are not so much of a concern, internal bleeding that can damage organs and tissues in the body can be dangerous and life threatening. Bleeding in the joints can cause chronic disease that is intensely painful; bleeding in the brain can cause seizures and long-term paralysis and if bleeding cannot be prevented or affects a vital organ, it can lead to death.
People with hemophilia have an abnormally low level of either factor VIII or factor IX in their blood and the severity of their condition depends on how lacking these factors are.
Hemophilia is an X-linked condition, meaning it mainly affects males. In the U.S, about one in every 5,000 males are affected each year. Worldwide, around 400,000 individuals have the condition, which affects all ethnicities and economic groups equally.
Genetics
The two main types of hemophilia are caused by gene mutations that affect the levels of clotting factors in the blood. Mutation of the FVIII gene leads to hemophilia A, also called classic hemophilia, while a mutations in the FIX gene leads to hemophilia B, also called Christmas disease.
As a recessive X-linked genetic disorder, the mutation that causes hemophilia is passed to offspring via the X chromosome. Hemophilia is more common among male children because they only inherit one X chromosome.
Humans have 22 pairs of autosomal chromosomes and one pair of sex chromosomes, making a total of 46 chromosomes in each cell. In males, there is both an X chromosome and a Y chromosome, whereas females have two X chromosomes. Male offspring inherit their X chromosome from their mother and their Y chromosome from their father, while female offspring inherit an X chromosome from each parent.
Since males only have one X chromosome, they will develop symptoms of hemophilia if that chromosome carries the mutation. However, because the condition is recessive, the inheritance of one abnormal X chromosome does not usually cause symptoms in females because they usually also inherit another normal X chromosome. These females are then classified as carriers of the disease and can pass on the mutation to male offspring even though they do not develop symptoms themselves. Technically, a female can develop hemophilia if she is born to a female carrier and a man affected by hemophilia, but this is very rare.
A female who carries a mutation for hemophilia has a 50% chance of passing the X chromosome that carries the mutation to her male offspring. The chance of her passing on the normal X chromosome that is not affected by this mutation is also 50%.
Although hemophilia runs in families, sometimes there is no family history of the condition when a child is born with it. Sometimes, female carriers are identified, but boys are not affected. In about one third of cases however, the child born with hemophilia is the first family member to develop the mutation.
Genetic testing
Genetic testing and genetic counselling are available for couples with a family history of hemophilia who may want to determine how likely it is their child would be born with the condition. Genetic analysis of the FVIII gene identifies a mutation in up to 98% of people who have hemophilia A and analysis of the FIX gene identifies a mutation in over 99% of those who have hemophilia B. Tests can also be performed to check for the gene during pregnancy using either amniocentesis or chorionic villus sampling.
Genetic research
Geneticists have been trying to develop a gene therapy for hemophilia A and the results have so far been encouraging. The long-term safety of gene therapies is still being carefully examined, but researchers hope that a genetic cure for the condition will eventually be available.
Explanation: