why solvents producing halogens not used in HPLC?
Answers
Answer:
The overwhelming majority of HPLC is reverse-phase (RP-HPLC), which is performed with water and aqueous-soluble solvents like acetonitrile. Halogenated solvents aren’t soluble in either, so that’s generally a problem. You don’t see much use of ethers or hexane or other water-insoluble solvents in HPLC either.
They also have the unfortunate side effect of dissolving resin stationary phases, so there’s a limit on which kinds of stationary phases you can employ: generally silica or alumina. And the separation power, in theoretical plates, Isn’t generally very high with these kinds of stationary phases.
Since most compounds of interest to people are ones that are at least a little compatible and soluble in water or aqueous- compatible environments, there isn’t probably much demand for HPLC systems that operate entirely in the absence of water: you can’t inject water into a halogenated solvent and expect it to behave well.
there are some applications, like polymer chemistry and size exclusion chromatography, where halogenated solvents might have some application, but with the rise in demand for low-VOC polymers and paints, the demand is not likely strong. So it’s less that it’s “not used”, but rather you don’t often see it used compared with the extreme abundance of RP-HPLC. And with the rise of SFC and the increasing sophistication of MS, I don’t see that changing anytime soon.
Explanation:
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