Why was Oxygen-16 replaced by Carbon-12 as the reference for measuring atomic masses
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so carbon-12 atom was taken as refrence atom. Earlier Oxygen was used as the reference for mass measurements. Then the O17, O18 isotopes of Oxygen were also discovered being present in the natural air/oxygen. ... Choosing oxygen needed making bigger changes.
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Physicists picked the pure isotope Oxygen-16, because they tended to make their measurements on the basis of mass spectrometry. Though the ratio of any two atom's masses was the same on either scale, it was horribly confusing, so in 1961, a compromise was reached.
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