write a note on miscellaneous chemical incompatibility
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Explanation:
Miscellaneous Chemical Incompatibilities:
1)Soluble barbiturates with ammonium bromide:-When soluble barbiturates is combined with ammonium bromide in the presence of water the barbitone is seperated as indiffusible precipitates which are insoluble in water .Hence follow method B for precipitate yielding interactions for dispensing the prescription.
2)Potassium chlorate with oxidisable substances:-When potassium chlorate is prescribed along with charcoal ,sulphur ,sugar organic compounds or any other readily oxidisable substances ,during dispensing if heating or trituration is done there are chances of explosion .Mixing of potassium chlorate with any dry substances is not advisable but if essential,the ingredients should be powdered seperately in a dry and clean mortar and then mixed gently with a clean powder spatula on a clean ointment tile,without any friction.
3)Incompatibility of emulsifying agents:Emulsions prepared with alkali metal,ammonium and triethanolamine soaps are incompatible with salts producing polyvalent cations .Due to double decomposition ,a polyvalent soap is formed whichinverts the emulsion.Sometimes an emulsifying agents cause an inversion in anemulsion product.
4)Colour stability of dyes:The colour of the most of the dyes used in pharmaceutical formulations are influenced by their ionization which depends on pH of the solution. The phenolphthalein dye is colourless in acid solution but red in alkaline mixture.Reducing agents often cause fading of colour Anionic dyes(amaranth,tartrazine)are most stable at acidicpH.Basic dyes (methylene blue,crystal violet )are often verysensitive to alkalis