Write a note on Screening of industrial important microbes.
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In the early 1990s, gene therapy was used to correct a deficiency of the enzymeadenosine deaminase (ADA).
Blood cells called lymphocytes were removed from the bone marrow of two children; then genes for ADA production were inserted into the cells using viruses as vectors.
Finally, the cells were reinfused to the bodies of the two children. Once established in the bodies, the gene-altered cells began synthesizing the enzyme ADA and alleviated the deficiency.
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Microoganisms isolated in the primary screening are critically evaluated in the secondary so that industrially important.
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