Question

Write a short note on hoffmann bromamide degradation

Answer 1

Hoffmann Bromamide degradation reaction is used to convert amide to amine to react with bromine and alkali followed by heating,it forms one carbon less amine than amide which is in the reactant.
Here is the reaction...
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Answer 2

ANSWER:

✔Hoffmann developed a method for preparation of primary amines by treating an amide with bromine in an aqueous or ethanolic solution of sodium hydroxide.

✔In this degradation reaction, migration of an alkyl or aryl group takes place from carbonyl carbon of the amide to the nitrogen atom.

✔The amide so formed contains one carbon less than that present in the amide.

⭐Reaction ----

RCONH2 + Br2 +4NaOH ➡RNH2 + Na2CO3 + 2NaBr + 2H2O