write short note on schmidt reaction
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The Schmidt reaction is an organic reaction in which an azide reacts with a carbonyl derivative, usually a aldehyde, ketone, or carboxylic acid, under acidic conditions to give an amine or amide, with expulsion of nitrogen.[1][2][3] It is named after Karl Friedrich Schmidt (1887–1971), who first reported it in 1924 by successfully converting benzophenone and hydrazoic acid to benzanilide.[4] Surprisingly, the intramolecular reaction was not reported until 1991[5] but has become important in the synthesis of natural products.[6]
Schmidt reaction
Named after
Karl Friedrich Schmidt
Reaction type
Rearrangement reaction
Identifiers
Organic Chemistry Portal
schmidt-reaction
RSC ontology ID
RXNO:0000170
Schmidt Reaktion Übersicht Carbonsäuren1.svg
The reaction is effective with carboxylic acids to give amines (above), and with ketones to give amides (below).
Schmidt Reaktion Übersicht Ketone1.svg
Reaction mechanism
Reactions involving alkyl azides
See also
References
Last edited 5 months ago by an anonymous user
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