Question

write the mechanism of neuromuscular junction ?

Answer 1

hope this helps u............

Answer 2

The neuromuscular junction is where a neuron activates a muscle to contract. Upon the arrival of an action potential at the presynaptic neuron terminal, voltage-dependent calcium channels open and Ca2+ions flow from the extracellular fluid into the presynaptic neuron's cytosol. This influx of Ca2+ causes neurotransmitter-containing vesicles to dock and fuse to the presynaptic neuron's cell membrane through SNAREproteins. Fusion of the vesicular membrane with the presynaptic cell membrane results in the emptying of the vesicle's contents (acetylcholine) into the synaptic cleft, a process known as exocytosis. Acetylcholine diffuses into the synaptic cleft and can bind to the nicotinic acetylcholine receptors on the motor endplate, causing calcium ions to flow into the muscle cell, initiating a sequence of steps that finally produce muscle contraction.