Write the symptoms of haemophilia and Sickle Cell anaemia in human explain how the inheritance pattern of the two disorder different from each other.
Answers
Symptoms of Haemophilia : Patient continues to bleed even on a minor cut as the patient does not possess natural phenomenon of blood clotting. <br> Symptoms of Sickle-cell Anaemia :
behaves as normal haemoglobin except under oxygen stress where erythrocytes lose their circular shape and become sickle-shaped. As a result, the cells cannot pass through narrow capillaries. Blood capillaries are clogged and thus affects blood supply to different organs.
Hemophilia A and hemophilia B are inherited in an X-linked recessive pattern. The genes associated with these conditions are located on the X chromosome, which is one of the two sex chromosomes. In males (who have only one X chromosome), one altered copy of the gene in each cell is sufficient to cause the condition.
Sickle cell anemia is inherited in an autosomal recessive pattern, which means that both copies of the gene in each cell have mutations . The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.
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