Question

Ypoxia amplifies the proinflammatory state of m1 macrophages and reprograms m2 macrophages towards a proinflammatory direction by increasing the production of inflammatory and proangiogenic cytokines/chemokines

Answer 1

We show that hypoxia amplifies the proinflammatory state of M1 macrophages and reprograms M2 macrophages towards a proinflammatory direction by increasing the production of inflammatory and proangiogenic cytokines/chemokines.

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Answer 2

The role of M1 macrophages is to secrete pro-inflammatory cytokines and chemokines, present antigens, and thus participate in the positive immune response and function as an immune monitor. The main pro-inflammatory cytokines it produces are IL-6, IL-12 and TNF-alpha.

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