Question

3. What should be the disadvantage of cross over study on volunteers ?

a) Minimize the inter subject variability in plasma drug levels
b) Minimize the carry-over effect
c) Minimizes variations due to time effect d) Takes a lot of time to get the result of the study​

Answer 1

Answer:

d) is the answer

i think this is correct for a student volunteers

Answer 2

(d)."Takes a lot of time to get the result of the study", disadvantage of cross over.

Explanation:

• The advantages of randomized, balanced cross-over study is it minimizes the intrasubject variability in plasma drugs levels, minimize the carry-over effect, minimizes variations due to time effect.
• Makes it possible to focus on formulation variables. but this method takes a long time because a specific time has to be given for the washout of the previous administration.
• Convenience sampling is a type of sampling that is often used by inexperienced researched, or perhaps, by those who wish to obtain specific result, which of course, is highly unethical.