Amino acid is expected to be at the core of a protein structure
a. Glutamine
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Crystal structures show that protein main chain and side chains occupy almost every available space
The interior has a packing density comparable to that of organic solid and is denser than organic liquid
packing density = van der Waals volume/Voronoi volume
van der Waals volume is the volume actually taken up by
atoms
Voronoivolume is the sum of the atomic volume, inner voids and the surface of empty spaces (as defined by the molecular surface) organic solid 0.68 –0.8
protein 0.72 – 0.77
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