Question

Based on your understanding of genetic code, explain the formation of any abnormal hemoglobin molecu

Answer 1

Answer:

There is a change in one codon GAG to GUG resulting in incorporation of valine instead of glutamic acid at the sixth position in the chain of β chain of hemoglobin. In the homozygous condition, the affected person dies before reaching maturity. In heterozygous condition, oxygen stress causes appearance of sickle cell anemia due to development of hydrophobic bonds.

Answer 2

Answer:

There is a change in one codon GAG to GUG resulting in incorporation of valine instead of glutamic acid at the sixth position in the chain of β chain of hemoglobin. In the homozygous condition, the affected person dies before reaching maturity. In heterozygous condition, oxygen stress causes appearance of sickle cell anemia due to development of hydrophobic bonds.