Question

Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase.

Answer 1

The site of action is the de novo f olate biosynthesis enzyme dihydropteroate synthase (DHPS) where sulfonamides act as analogues of one of the substrates, para-aminobenzoic acid (pABA). We report here the crystal structure of E.coli DHPS at 2.0 Å resolution refined to an R-factor of 0.185